We saw rookie quarterbacks play for the first time in NFL Week 4, with Bailey Zappe of the Patriots getting the first rookie touchdown pass of 2022. Kenny Pickett is now the starting quarterback in Pittsburgh, putting an end to the three-game era of Mitchell Trubisky.

We still have one unbeaten, the Eagles, but our 0-3 team, the Raiders, got its first win of the NFL season. The Chiefs reinserted themselves into the Super Bowl favorites conversation, and the 49ers did, too, with a dominant defensive performance against the Rams.

More on the Niners and Rams in our best picks for this coming NFL weekend.

New York Giants (+8) vs. Green Bay Packers

We start in London, where the Green Bay Packers are playing for the first time. They are the final of the NFL’s 32 teams to make the trip to England, and for the first time in the history of the London series, we have two winning teams playing each other.

The Giants are playing good defense, and Saquon Barkley is playing like a rushing champion, and the Packers don’t look like a team ready to win a blowout. New York keeps it close, meaning you should take the points.

Pittsburgh Steelers (+14) at Buffalo Bills

The Bills are much better offensively than the Steelers, and they are much better defensively. But the Bills aren’t playing their best football right now, and if rookie Kenny Pickett can protect the football, the Steelers should keep this margin at less than two touchdowns.

Buffalo is banged up, and the offense is out of sequence at the moment; and this is a huge spread for a team that has averaged just 21 points per game the last two weeks. Buffalo wins, but your money should go on Pittsburgh to cover.

San Francisco 49ers (-6) at Carolina Panthers

If there is a team that deserves a 14-point spread, it’s the Niners over the Panthers.

San Francisco’s defensive line just dominated a much better offense in the Rams, and they will have a field day against Baker Mayfield. Carolina, despite having great skill players, may not score in this game. The Niners’ defense is playing that well.

Add in Deebo Samuel at the height of his powers, and the Niners giving six points feels like a no-brainer.

Dallas Cowboys (+4) at Los Angeles Rams

That Rams offensive line that was just dominated by the 49ers now has to play Micah Parsons and the Dallas defense. Sean McVay is one of the best offensive schemers in the business, but he will not have an answer for Parsons, Demarcus Lawrence, Dante Fowler, and Dorance Armstrong.

If the Rams manage to win this NFL game, it will be a low-scoring win by a field goal. Take the Cowboys and the points.

Pay Per Head Software

There is no sports betting quite like NFL betting. And no bookmaking like the bookmaking that comes with a top pay per head software provider like WagerHome.com.

Independent bookies, with a WagerHome partnership, you get your own fully customizable website, access to WagerHome’s huge menu of sports and betting options, plus EZ live betting.

See a demo today at WagerHome.com and get your first four weeks absolutely free.